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Aggregation suppression of human γD-crystallin by CCT5 and its neuropathy mutant. Aggregation of WT (A, orange) or Y92A/Y97A (B, orange) human γD-crystallin (HγD-Crys, HγD) was suppressed more efficiently by WT CCT5 (blue) than by H147R CCT5 (magenta). Without human γD-crystallin, WT CCT5 (purple) and H147R CCT5 (green) did not show any self-polymerization. The curves are representative; the assays were repeated three to five times and showed the same trends.
