TABLE 1.

Mutations in chaperonin genes leading to neuropathy diseases

Protein	Mutation	Domain	Inheritance	Identified	Disease
CCT4	C450Y	Equatorial	Recessive	Sprague-Dawley rats	Hereditary sensory neuropathyb
CCT5	H147R	Equatorial	Recessive	Moroccan family	Mutilating sensory neuropathyc
HSPD1a	V98I	Equatorial	Dominant	French family	Hereditary spastic paraplegiad

^a Human mitochondrial Hsp60.

^b Ref. 7.

^c Ref. 5.

^d Ref. 6.