TABLE 2.
Pathophysiological and biochemical characterization of ethanol-exposed mouse model
Data are expressed as mean ± S.E. (n = 5). The following abbreviations are used: BW, body weight; Wt, weight; ALT, alanine aminotransferase; BAL, blood alcohol level. BAL −, <20 mg/dl.
| Control | EtOH | IL-6 KO | IL-6 KO plus EtOH | |
|---|---|---|---|---|
| Final BW (g) | 21.33 ± 0.63 | 23.55 ± 0.57 | 20.08 ± 0.54 | 24.21 ± 0.62 |
| Liver Wt (g) | 1.21 ± 0.05 | 2.38 ± 0.14a | 1.44 ± 0.06 | 2.55 ± 0.17a |
| Liver Wt/body weight (%) | 5.67 ± 0.11 | 10.10 ± 0.46a | 7.17 ± 0.23 | 10.53 ± 0.38a |
| ALT (units/liter) | 68.00 ± 10.23 | 531.60 ± 63.44a | 84.67 ± 15.43 | 954.33 ± 85.62a,b |
| BAL (mg/dl) | − | 234.53 ± 19.23 | − | 227.54 ± 17.69 |
| Total path scores | 0.60 ± 0.32 | 4.30 ± 0.52a | 0.92 ± 0.58 | 6.32 ± 0.75a,b |
| Morbidity (%) | 0 | 0 | 0 | 40 |
a p <0.05 compared with control.
b p <0.05 compared with IL-6 KO. IL-6 KO, IL-6 knockout mice.