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Role of phosphatases in metformin mediated down-regulation of mTOR signaling. A and B, phosphatase inhibitor reversed metformin (Met)-mediated down-regulation of mTOR signaling. Panc28 and L3.6pL cells were pretreated with phosphatase inhibitor SOV (20 μm) for 45 min followed by treatment with 15 mm metformin for 36 h, and whole cell lysates were analyzed by Western blots. C, proposed mechanism of action of metformin in pancreatic cancer. IGFR, IGF-1R. P, phosphorylation.
