TABLE 2.

Sensitivity of parental and vemurafenib-resistant melanoma cell lines to cisplatin, melphalan, and temozolomide

Cell line	IC50 values
	Cisplatin	Melphalan	Temozolomide
	μm
A375	0.6	2.3	0.2
A375rVem	2.1	14.6	1.0
-Fold resistancea	3.5	6.35	5.0
DM443	7.7	110	0.8
DM443rVem	10.2	175	2.2
-Fold resistancea	1.30	1.60	2.75

^a -Fold resistance is defined as the IC₅₀ (resistant cell line)/IC₅₀ (parental cell line).