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. 2014 Aug 8;289(40):27757–27765. doi: 10.1074/jbc.M114.571810

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© 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 4. — RhoA inhibition provides a priming signal for IL-1β release. Messenger RNA of THP-1 cells treated with RhoA inhibitor is isolated, and induction of four genes is determined in comparison to untreated control cells. Simvastatin treatment is taken as the broad-ranging prenylation inhibitor. Of the four genes, only IL-1β (A) is significantly up-regulated. The related cytokine IL-18 (B) and the inflammasome components NLRP3 (C) and caspase-1 (D) show no difference. All genes are normalized to GAPDH; bar graphs represent the average of three independent experiments.