Figure 1.

Effect of the PARP inhibitor, rucaparib, on clonogenic survival of LoVo cells. Exponentially growing LoVo cells were treated with increasing concentrations of CPT in the presence ( ○ ) or absence ( ● ) of rucaparib for (A) 24 h or (B) 1 h. The comparison between incubating LoVo cells either as a monolayer or in suspension is also shown in (B), where cells in suspension were exposed to CPT in the presence (Δ) or absence (▴) of rucaparib.