Table 1. Association of nBAP1 status with clinical, pathological and genetic risk factors in UM.
| Variable | nBAP1 absent | nBAP1 present | P-value |
|---|---|---|---|
|
Age at PM (years) | |||
| Mean | 65.4 | 55.2 | 0.002 |
| Median | 65.0 | 57.0 | |
| Range |
38.0–89.0 |
21.0–79.0 |
|
|
Gender | |||
| Female | 22 (50%) | 22 (50%) | 0.747 |
| Male |
13 (54%) |
11 (46%) |
|
|
LBD (mm) | |||
| Mean | 16.9 | 16.0 | 0.151 |
| Median | 17.5 | 15.9 | |
| Range |
10.8–21.1 |
12.2–21.5 |
|
|
UH (mm) | |||
| Mean | 9.6 | 8.6 | 0.157 |
| Median | 9.7 | 9.0 | |
| Range |
3.4–15.7 |
2.4–14.0 |
|
|
Ciliary body involvement | |||
| Yes | 17 (81%) | 4 (19%) | 0.001 |
| No |
18 (38%) |
29 (62%) |
|
|
Epithelioid cells present | |||
| Yes | 29 (62%) | 18 (32%) | 0.011 |
| No |
6 (29%) |
15 (71%) |
|
|
Closed loops present | |||
| Yes | 27 (69%) | 12 (31%) | 0.001 |
| No |
8 (28%) |
21 (72%) |
|
|
Mitotic count per 40 HPF | |||
| Mean | 8.3 | 6.7 | 0.235 |
| Median | 7.0 | 5.0 | |
| Range |
1.0–23.0 |
1.0–16.0 |
|
|
Monosomy 3 | |||
| Yes | 25 (66%) | 13 (34%) | 0.001 |
| No | 8 (29%) | 20 (71%) | |
| Not available | 2 (100%) | 0 | |
Abbreviations: HPF=high-power fields; LBD=largest basal diameter; PM=primary management; nBAP1=nuclear BRCA1-associated protein 1; UH=ultrasound height.