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. 2014 Jul 29;111(7):1338–1349. doi: 10.1038/bjc.2014.426

Figure 7.

Figure 7

Isoflurane exposure enhanced human prostate cancer cell migration and invasion. (A and B) ELISA assessment of MMP-2 and MMP-9 in the cell culture medium. (C and D) Scratch assay of PC3 cells before and 24 h after exposure to isoflurane demonstrated accelerated gap closure, while propofol at 4 μg ml−1 or HIF-1α-specific siRNA (20 nM) abolished these changes. Results are mean±s.d. (n=4); *P<0.01 and ***P=0.001; #P<0.001, naive control vs isoflurane alone. Abbreviations: HSi=HIF-1α siRNA; Iso=isoflurane; NC=naive control; Pro=propofol; SSi=scrambled siRNA.