Table 3.
Genotype Frequencies of ERCC2 Gene Polymorphisms in Controls and Cases and Their Associations with Breast Cancer
| SNPs | Genotype | Case n (%) | Control n (%) | OR (95% CI)a | p-Value | pc |
|---|---|---|---|---|---|---|
| rs3916840 | CC | 91 (90.1) | 90 (89.1) | Reference | ||
| CT | 10 (9.9) | 11 (10.9) | 0.889 (0.364–2.222) | 0.818 | NS | |
| TT | 0 | 0 | ||||
| C | 192 (95.1) | 191 (94.6) | Reference | |||
| T | 10 (4.9) | 11 (5.4) | 0.904 (0.375–2.179) | 0.823 | NS | |
| rs1799793 | GG | 84 (83.2) | 89 (88.1) | Reference | ||
| GA | 17 (16.8) | 12 (11.9) | 1.501 (0.667–3.330) | 0.316 | NS | |
| AA | 0 | 0 | ||||
| G | 185 (91.6) | 190 (94.1) | Reference | |||
| A | 17 (8.4) | 12 (5.9) | 1.455 (0.676–3.130) | 0.335 | NS | |
| rs238416 | GG | 52 (51.5) | 25 (24.7) | Reference | ||
| GA | 37 (36.6) | 62 (61.4) | 0.287 (0.153–0.537) | <0.001 | <0.01 | |
| AA | 12 (11.9) | 14 (13.9) | 0.412 (0.166–1.020) | 0.052 | NS | |
| G | 141 (69.8) | 112 (55.4) | Reference | |||
| A | 61 (30.2) | 90 (44.6) | 0.538 (0.358–0.810) | 0.003 | 0.027 | |
| Dominantb | 0.310 (0.171–0.563) | <0.001 | <0.01 | |||
| Recessivec | 0.838 (0.367–1.913) | 0.674 | NS |
a
ORs were adjusted for age of onset.
b
The dominant model: comparing the combination of heterozygotes and minor allele homozygotes with the major allele homozygotes.
c
The recessive model: comparing minor allele homozygotes with the combination of heterozygotes and major allele homozygotes.
CI, confidence interval; ERCC2, excision repair cross-complementing group 2; NS, not significant; OR, odds ratio; pc, corrected p-value (after Bonferroni multiple adjustment).