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. 2014 Oct 1;3(10):647–661. doi: 10.1089/wound.2013.0517

Figure 4.

Figure 4.

VEGF–VEGFR binding partners. VEGF-A belongs to a family of VEGF proteins that also includes VEGF-B, VEGF-C, VEGF-D, and PlGF. Each family member binds to one or more tyrosine kinase receptors of the VEGFR family (VEGFR-1, -2, and -3). Soluble forms of some VEGFRs exist, including sVEGFR-1, which binds to VEGF and blocks its ability to signal through the membrane-bound forms of the receptors. Some VEGF family members can also bind to NRPs, which function as coreceptors. NRP, neuropilin; VEGFR, VEGF receptor.