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. 2014 Sep 26;46(9):e115. doi: 10.1038/emm.2014.59

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Copyright © 2014 KSBMB.

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Inhibition of preeclampsia (PE)-induced calcium influx in cocultured human umbilical artery smooth muscle cells (HUASMCs) by phospholipase C-γ1 (PLC-γ1) and 1,4,5-trisphosphate receptor (IP₃R) small interfering RNA (siRNA). (a) Calcium accumulation in the HUASMCs treated with normal (N) serum, N+PLC-γ1-siRNA serum, N+IP₃R-siRNA serum, PE serum, PE+PLC-γ1-siRNA serum and PE+IP₃R-siRNA serum. (b) Fluorescence intensity of calcium influx in the cocultured HUASMCs. Data are presented as the mean±s.d. of 20 samples per group. ^†Significantly different compared with the other five groups, P<0.001.