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. 2014 Sep 26;46(9):e115. doi: 10.1038/emm.2014.59

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Copyright © 2014 KSBMB.

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/

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Effects of preeclampsia (PE) serum on protein kinase C-α (PKC-α) expression and activity, as well as collagen expression by cocultured human umbilical artery smooth muscle cells (HUASMCs). (a) Cytosolic and membrane PKC-α (c-PKC-α and m-PKC-α, respectively) expression. ^†Significantly different compared with the other three groups, P<0.05. (b) PKC-α activity. ^†Significantly different compared with the other three groups, P<0.05. (c) Collagen I and procollagen III expression in cocultured HUASMCs treated with normal (N) and PE sera without and with phospholipase C-γ1 (PLC-γ1) small interfering RNA (siRNA) or 1,4,5-trisphosphate receptor (IP₃R) siRNA. Data are presented as the mean±s.d. of 20 samples per group. ^†Significantly different compared with the first three groups (N, N+IP₃R-siRNA and N+PLC-γ1-siRNA), P<0.001. ^‡Significantly different compared with the PE and PE+IP₃R-siRNA groups, P<0.001.