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. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: Crit Rev Oncog. 2014;19(0):281–315. doi: 10.1615/critrevoncog.2014011455

TABLE 1.

Histological subtypes of epithelial ovarian cancer and associated genetic mutations2–7,11

Histologic subtype Percentage of EOC cases (%) Most common genetic changes Tissue of origin
Serous, high grade (type II)* 70 TP53 (96%)
BRCA1/BRCA2 (22%)		 Fallopian tube fimbria
Serous, low grade (type I) <5 BRAF/KRAS (50%)
ERBB2 (9%)		 Fallopian tube fimbria
Clear cell (type I) 10 ARIK1A (50%)
PIK3CA (50%)
PTEN (20%)		 Endometrial/endometriosis
Endometrioid (low grade, type I; high grade, type II) 10 CTNNB1 (40%)
PIK3CA (20%)
PTEN (20%)		 Endometrial/endometriosis
Mucinous (type I) <5 KRAS (75%) —