TABLE 2.
Summary of nanoparticle agents used for ovarian cancer imaging
| Imaging modality | Nanoparticle | Targeting | Drug | Specimen | Cell line | Refs |
|---|---|---|---|---|---|---|
| Optical | Quantum dot | CA125-antibody | N | Xenograft | HO8910 | 71 |
| Quantum dot | EPR | N | Xenograft | HEYA8 | 70 | |
| Quantum dot | Her2-antibody | N | In vitro | SKOV-3 | 72 | |
| Quantum dot | MUC1-aptamer | Y | Xenograft | A2780 | 73 | |
| Polymethacrylic acid (VIS) | Her2-antibody | In vitro | SKOV-3 | 184 | ||
| Lipoprotein (NIR) | Folic acid | Xenograft | — | 185 | ||
| PEG-PLA (NIR) | EPR | Xenograft | A2780 | 68 | ||
| PEG-lipid (NIR) | EPR | Xenograft | SKOV-3 | 69 | ||
| NaYF4:Yb3+/Er3+ @ SiO2 | — | In vitro | SKOV-3 | 186 | ||
| Magnetic resonance | Dendrimer | Biotin | Xenograft | SHIN3 | 62 | |
| Liposome | Folic acid | Xenograft | IGROV-1, OVCAR-3 | 63 | ||
| Iron oxide | Folic acid | In vitro | SKOV-3 | 64 | ||
| Iron oxide/Gd | EPR | Xenograft | SKOV-3 | 65 | ||
| Photo acoustic | Gold nanorods | EPR | Xenograft | 2008, HEY, SKOV-3 | 75 | |
| Ultrasound | Liposome microbubbles | — | In vivo | N/A | 56, 57 |