MEST score distribution in the VALIGA cohort of patients with IgA nephropathy (IgAN). The whole cohort (A); patients with advanced chronic kidney disease (estimated glomerular filtration rate <30 ml/min per 1.73m2) (B); patients with proteinuria <0.5 g/day (C), ⩾0.5, and <1 g/day (D); patients with proteinuria ⩾1 and <3 g/day (E); and patients with proteinuria >3 g/day (F). Renal biopsies were scored according to Oxford classification: mesangial score >0.5 (M1), any endocapillary hypercellularity (E1), any segmental sclerosis (S1), tubular atrophy, and interstitial fibrosis (T1 and T2), arterial intimal thickening (present), any crescent (present).