Table 3. Correlations between pathological features and outcomes.
|
Rate of renal function decline |
Survival from renal failure or 50% drop in eGFR |
|||
|---|---|---|---|---|
| Univariate (ml/min per 1.73 m2/year) | Multivariate ß (s.d.)a | Univariate hazard ratio (95% CI) | Multivariate hazard ratio (95% CI)a | |
| Mesangial proliferation | ||||
| M0 | −1.29±7.49 | 1 | 1 | |
| M1 | −3.02±7.32 | −0.9 (0.5) | 2.3 (1.7–3.0) | 1.3 (0.9–1.7) |
| P<0.001 | P=0.04 | P<0.001 | P=0.12 | |
| Segmental glomerulosclerosis | ||||
| S0 | −1.15±5.46 | 1 | 1 | |
| S1 | −2.03±8.18 | −0.1 (0.5) | 4.1 (2.6–6.5) | 1.8 (1.1–2.9) |
| P=0.03 | P=0.85 | P<0.001 | P=0.02 | |
| Tubular atrophy/interstitial fibrosis | ||||
| T0 | −1.36±7.29 | 1 | 1 | |
| T1–2 | −3.28±7.97 | −1.4 (0.6) | 5.6 (4.2–7.5) | 2.6 (1.8–3.6) |
| P<0.001 | P=0.01 | P<0.001 | <0.001 | |
Abbreviations: CI, confidence interval; eGFR, estimated glomerular filtration rate.
Mesangial score >0.5 (M1), any endocapillary hypercellularity (E1), any segmental sclerosis (S1), tubular atrophy, and interstitial fibrosis (T1 and T2).
a
Multivariate models are adjusted for initial eGFR, follow-up blood pressure, and proteinuria.