Table 3.
Serum Estrone and 17β-Estradiol Before/After Six Weeks of Placebo or Estrogen Cream
| Placebo Group |
Estrogen Group |
Pretherapy Comparison |
Posttherapy Comparison |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Before (n = 15) | After (n = 13) | P Valuea | Before (n = 15) | After (n = 12) | P Valuea | df | t | P Valueb | df | t | P Valuec | |
| E1 | 18.5 ± 3.9 | 24.9 ± 6.5 | .06 | 18.0 ± 2.3 | 22.8 ± 3.5 | .05 | 28 | 0.11 | .91 | 23 | 0.28 | .78 |
| E2 | 8.4 ± 1.6 | 11.6 ± 2.7 | .24 | 11.1 ± 3.7 | 7.8 ± 1.3 | .49 | 28 | 0.67 | .51 | 23 | 1.23 | .24 |
| (n = 15) | (n = 13) | P Valuea | (n = 8) | (n = 8) | P Valuea | P Valueb | P Valuec | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| E1d | 18.5 ± 3.9 | 24.9 ± 6.5 | .06 | 19.8 ± 2.9 | 27.7 ± 4.2 | .05 | 21 | 0.22 | .81 | 19 | 0.31 | .76 |
| E2d | 8.4 ± 1.6 | 11.6 ± 2.7 | .24 | 13.1 ± 5.0 | 9.3 ± 1.6 | .31 | 21 | 1.12 | .32 | 19 | 0.62 | .56 |
Abbreviations: df, degrees of freedom; t, t statistic. Data are mean ± SEM (picograms per milliliter).
a
Within-group paired t test.
b
Between-group t test before therapy.
c
Between-group t test after therapy.
d
Data exclude nonadherent patients (ie, per protocol only participants).