Figure 1.

A, General study protocol. Subjects reported to the CRC in sodium balance on either a low-sodium (LS) or high-sodium-controlled diet (HS) and received either drug or vehicle infusion overnight and hyperglycemic clamps (HGC) the next morning. Subjects crossed over and received the remaining infusion on study day 2. B, Hyperglycemic clamp protocol. After insertion of catheters, baseline measurements were performed, and iv dextrose was infused to achieve hyperglycemia (∼200 mg/dL). Glucose was measured every 5 minutes, and dextrose infusion was adjusted to maintain hyperglycemia.