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. Author manuscript; available in PMC: 2014 Oct 3.
Published in final edited form as: J Surg Res. 2013 Jan 1;184(2):730–738. doi: 10.1016/j.jss.2012.12.009

Figure 2. Potential targets for bacterial binding and interference with epithelial restitution.

Figure 2

We hypothesized several points of interaction between P. aeruginosa bacteria and epithelial cells which could lead to inhibition of epithelial restitution. Mechanism 1 involves binding to integrin-α3β1, which is involved in pro-motility signaling through Rac1. Mechanism 2A and 2B involve binding to the extracellular matrix laminins 332 and 511, respectively. Mechanism 3 involves inhibition of LM-332 production by bacteria.