Table 1.
Maternal Characteristics and Confirmatory HIV-1 Testing in 4 Infants
| Characteristic | Case 1 | Case 2 | Case 3a | Case 4a |
|---|---|---|---|---|
| Maternal characteristics | ||||
| Age | 30 y | 32 y | 29 y | 29 y |
| Viral load prior to deliveryb | 97 701 c/mL | Unknownc | 6326 c/mL | 6326 c/mL |
| CD4+ T-cell count prior to deliveryb | 190 cells/µL | 10 cells/µL | 61 cells/µL | 61 cells/µL |
| Clade | G (CRF 6) | Unknown | C | C |
| Infant characteristics | ||||
| Mode of delivery | Emergency cesarean | Spontaneous | Spontaneous | Spontaneous |
| Gestational age at birth | 34 wk plus 4 d | 27 wk | 36 wk | 36 wk |
| Birth weight | 2980 g | 1070 g | 2270 g | 1640 g |
| HIV PCR (age) | Positive (1 d) | Positive (2 d) | Positive (1 d) | Positive (1 d) |
| CD4+ T cell count at 4 wk | 3940 cells/µL (55.2%) | 1447 cells/µL (28.9%) | 2227 cells/µL (50.9%) | 1690 cells/µL (48.7%) |
| HIV viral load (age) | 1890 c/mL (1 d), 276 c/mL (28 d), 86 c/mL (107 d) |
235 c/mL (26 d), 81 c/mL (50 d) |
186 c/mL (13 d), 101 c/mL (38 d) |
795 c/mL (12 d), 61 c/mL (80 d) |
| Age at which sustained VL <50 c/mL was achieved | 189 d | 90 d | 66 d | 108 d |
Abbreviations: c/mL, copies/mL; CRF, circulating recombinant form; HIV, human immunodeficiency virus; PCR, polymerase chain reaction; VL, viral load.
a Nonidentical twins.
b Timing in relation to delivery (weeks prior): case 1, 3 weeks prior; case 2, onset of labor; case 3, within 24 hours of delivery; case 4, within 24 hours of delivery.
c Presented with catastrophic cerebral event (suspected cerebral toxoplasmosis); died soon after delivery.