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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Biochim Biophys Acta. 2013 Jun 6;1840(2):847–875. doi: 10.1016/j.bbagen.2013.05.040

Table 1.

Second order rate constants and conditions for H2O2 mediated oxidation of some biological small molecule thiols.

Thiol pKa Rate constant (M−1 s−1) Conditions References
Penicillamine 7.9 4.5 37 °C, pH 7.4 [77]
Cysteine 8.3 2.9 37 °C, pH 7.4 [77]
1.0 20 °C, pH 7.4 [78]
Cysteamine 8.3 2.9 37 °C, pH 7.4 [77]
1.1 20 °C, pH 7.4 [78]
Glutathione 8.8 0.9 37 °C, pH 7.4 [77]
Dithiothreitol 9.1 0.4 37 °C, pH 7.4 [77]
0.3 25 °C, pH 7.4 [189]
N-Acetylcysteine 9.5 0.2 37 °C, pH 7.4 [77]
0.9 25 °C, pH 7.4 [190]