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. 2014 Mar 4;1(3):199–208. doi: 10.1002/acn3.45

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© 2014 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Aged LRRK2^R1441G knockin mice have similar amounts of DA neurons and neurites compared to wild-type mice. (A, B) No apparent difference in the expression pattern of TH and DAT in SNpc and striatum between WT/WT and KI/KI mice at 18–22 months (N = 3). Scale = 150 μm in (A) and 200 μm in (B). (C) Statistical analysis of TH⁺ DA neurons numbers and neurite intensity of stained SNpc and striatum revealed no significant difference in combination of TH expression and cell count (unpaired Student's t-test, N = 3). (D) Western blot showed similar expression levels of TH and DAT (glycosylated and nonglycosylated) in striatum and midbrain in WT/WT and KI/KI mice at 3 and 18 months of age (N = 3).