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Kinetic parameters of S-naproxen glucuronidation in liver microsomes
| Liver microsomes | Equation | Km (μmol/L) | Vmax (nmol/min/mg) | Clearance (CLint) (μL/min/mg) |
|---|---|---|---|---|
| Humanized UGT1 mice | Michaelis–Menten | 465 ± 14 | 5.60 ± 0.09 | 12.0 ± 0.2 |
| Human | Michaelis–Menten | 308 ± 30 | 1.72 ± 0.11 | 5.6 ± 0.2 |
| Regular mice | Michaelis–Menten | 703 ± 54 | 10.0 ± 0.4 | 14.2 ± 0.5 |
