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IC50 values for the inhibition of furosemide glucuronidation in liver microsomes
| Liver microsomes | Estradiol (μmol/L) | Imipramine (mmol/L) | Serotonin (mmol/L) | Propofol (μmol/L) | AZT (μmol/L) |
|---|---|---|---|---|---|
| Humanized UGT1 mice | 32.5 | 0.25 | 0.61 | 186 | >500 |
| Human | 31.7 | 1.2 | >5 | 474 | >500 |
| Regular mice | 110.8 | 0.78 | 0.45 | 169 | >500 |
