Table 5.
Summary of recommended pharmacological treatments for premature ejaculation
| Drug | Daily dose/on demand | Dose | IELT fold increase | Side effects | Status | Level of evidence |
|---|---|---|---|---|---|---|
| Oral Therapies | ||||||
| Dapoxetine [184] | On demand | 30–60 mg | 2.5–3 | Nausea Diarrhea Headache Dizziness | Approved in some countries | 1a |
| Paroxetine [186] | Daily dose | 10–40 mg | 8 | Fatigue Yawning Nausea Diarrhea Perspiration Decreased Sexual Desire Erectile Dysfunction | Off label | 1a |
| Clomipramine [178,180] | Daily dose | 12.5–50 mg | 6 | Off label | 1a | |
| Sertraline [183] | Daily dose | 50–200 mg | 5 | Off label | 1a | |
| Fluoxetine [194] | Daily dose | 20–40 mg | 5 | Off label | 1a | |
| Citalopram [179] | Daily dose | 20–40 mg | 2 | Off label | 1a | |
| Paroxetine [185] | Daily dose for 30 days and then on demand | 10–40 mg | 11.6 | Off label | 1a | |
| Paroxetine [185] | On demand | 10–40 mg | 1.4 | Off label | 1a | |
| Clomipramine [187] | On demand | 12.5–50 mg | 4 | Off label | 1a | |
| Topical therapy | ||||||
| Lidocaine/Prilocaine [210] | On demand | 25 mg/gm lidocaine 25 mg/gm prilocaine | 4–6.3 | Penile numbness Partner genital numbness Skin irritation Erectile dysfunction | Off label | 1a |