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. 2014 Apr 14;1(5):340–347. doi: 10.1002/acn3.60

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© 2014 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Association between age and progression of percent brain atrophy at month 24. The Xs (riluzole) tend to be a bit shifted to the right compared to the circles (placebo) showing the older average age in the riluzole group. Although there are some older patients with more severe decline in the riluzole group, which could partially explain the differences, the largest declines in percent brain volume change (worse than 2%) were mostly in the treatment group (seven riluzole vs. one placebo subject) and were irrespective of age. In addition, a worsening in percent brain volume change worse than 1% at month 24 was seen almost equally in the placebo (n = 6) and the riluzole (n = 8) groups.