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. 2014 Mar 24;2(2):e00023. doi: 10.1002/prp2.23

Figure 9.

Figure 9

Compound AP2469 inhibits Aβ1-42 oligomer-induced NO (A) and TNFα (B) release in THP-1 cells. THP-1 cells were treated for 3 h with compound AP2469 (30 μmol/L) prior to the treatment for 12 h with Aβ1-42 oligomer (5 μmol/L). At the end of incubation, NO and IL-1 release was estimated using the Griess reagent and Ray Bio® ELISA kit, respectively (as described in the Materials and Methods section). The results are expressed as a percentage of control cells and the values are reported as mean ± SD of three independent experiments (°°P < 0.01 vs. untreated cells and *P < 0.05 vs. treated cells with Aβ1-42 oligomers at Student's t-test).