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. 2014 Mar 24;2(2):e00036. doi: 10.1002/prp2.36

Figure 1.

Figure 1

Apparent permeability of transepithelial vigabatrin (1.0 mmol/L) transport across Caco-2 cell monolayers in the presence or absence of infant formula. (A) The permeability (Papp) was measured in the presence or absence of 35.0 mmol/L Trp, infant formula or 20 mg mL−1 (151.4 mmol/L) Gly-Gly or Gly-Sar (136.9 mmol/L). (B) Vigabatrin permeability in the absence or presence of 20 mg mL−1 BCH (128.9 mmol/L) or Ile (152.5 mmol/L). Permeability was measured across Caco-2 cells cultured for 20 days on transwell filters. Dark gray control is the vigabatrin permeability in HBSS buffer, light gray columns are in NaCl-reduced HBSS. Columns represent mean ± SEM of permeability measured in 3–4 passages. ANOVA followed by Dunnett's multiple comparison test. *Significant difference from both controls (P < 0.05).