Figure 2.

The plasma concentration time profile of vigabatrin after oral administration of 1.0 or 10.0 mg kg⁻¹ vigabatrin to male Sprague–Dawley rats. (A) The rats received solutions containing 1.0 mg kg⁻¹ vigabatrin alone or coadministered with 1500 mg kg⁻¹ infant formula or low fat infant formula. (B) The rats received solutions containing 1.0 mg kg⁻¹ vigabatrin alone or coadministered with 100 mg kg⁻¹ (86.9 mmol/L) Pro and (49.0 mmol/L) Trp, 200 mg kg⁻¹ (224.5 mmol/L) Sar or (128.9 mmol/L) BCH. (C) The rats received solutions containing 10.0 mg kg⁻¹ vigabatrin alone or coadministered with 1500 mg kg⁻¹ infant formula or low fat infant formula or 200 mg kg⁻¹ Sar. Data points represent mean ± SEM from six different animals.