Table 1.
Overview of the formulations administered to Sprague–Dawley rats.
| Formulation | Route of adm. | Dose, mg kg−1 | Dose, mg kg−1 | Dose, mg kg−1 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Vigabatrin | Infant formula | Low fat infant formula | Pro | Trp | Sar | BCH | Acetaminophen | ||
| 0 | iv | 1 | – | – | – | – | – | – | – |
| 1 | PO | 1 | – | – | – | – | – | – | – |
| 2 | PO | 1 | 1500 | – | – | – | – | – | – |
| 3 | PO | 1 | – | 1500 | – | – | – | – | – |
| 4 | PO | 1 | – | – | 100 | 100 | – | – | – |
| 5 | PO | 1 | – | – | – | – | 200 | – | – |
| 6 | PO | 1 | – | – | – | – | – | 200 | – |
| 7 | PO | 10 | – | – | – | – | – | – | – |
| 8 | PO | 10 | 1500 | – | – | – | – | – | – |
| 9 | PO | 10 | – | 1500 | – | – | – | – | – |
| 10 | PO | 10 | – | – | – | – | 200 | – | – |
| 00 | iv | – | – | – | – | – | – | – | 120 |
| 11 | PO | 10 | – | – | – | – | – | – | 120 |
| 12 | PO | 10 | 1500 | – | – | – | – | – | 120 |
| 13 | PO | 10 | – | 1500 | – | – | – | – | 120 |
| 14 | PO | 10 | – | – | – | – | 200 | – | 120 |
The doses listed correspond to concentrations of 86.9 mmol/L Pro, 49.0 mmol/L Trp, 224.5 mmol/L Sar, 128.9 mmol/L BCH, and 79.4 mmol/L acetaminophen in the solutions administered.