Table 3.

Estimated pharmacokinetic parameters after oral administration of 10 mg kg⁻¹ vigabatrin to rats.

Formulation	7	8	9	10
Route of adm.	PO	PO	PO	PO
Dietary component	None	Infant formula	Low fat infant formula	Sar
AUC0–∞ (h ng mL−1)	17810 ± 808	17699 ± 533	16460 ± 267	15946 ± 816
tmax (h)	0.33 [0.25; 0.33]	0.67 [0.67; 1.00]*	0.67 [0.58; 0.67]*	0.67 [0.67; 0.67]*
Cmax (ng mL−1)	13567 ± 953	9237 ± 731*	9087 ± 301*	9485 ± 738*
CL (mL h−1 kg−1)	567 ± 24	568 ± 18	608 ± 10	635 ± 32
ke (h−1)	0.7 ± 0.0	0.7 ± 0.0	0.7 ± 0.0	0.8 ± 0.0
Fabs (%)	74 ± 3	73 ± 2	68 ± 1	66 ± 3

C_max, AUC_0–∞, CL, k_e and F_abs are expressed as mean ± SEM, t_max is expressed as the median [Q1; Q3] (25% and 75% percentile) from six rats.

^*Significant difference from oral administration of vigabatrin 10.0 mg kg⁻¹ (P < 0.05).