Table 4.

Estimated pharmacokinetic parameters after oral administration of 120 mg kg⁻¹ acetaminophen to rats.

Formulation	00	11	12	13	14
Route of adm.	iv	PO	PO	PO	PO
Dietary component	None	None	Infant formula	Low fat infant formula	Sar
AUC0–∞ (h μg mL−1)	155 ± 4	104 ± 20	90 ± 6	99 ± 13	105 ± 14
tmax (h)		0.21 [0.15; 0.33]	0.67 [0.50; 0.67]*	0.33 [0.33; 0.67]	0.33 [0.21; 0.22]
Cmax (μg mL−1)		76 ± 6	49 ± 4*	58 ± 7	72 ± 5
CL (mL h−1 kg−1)	775 ± 22	1413 ± 277	1354 ± 87	1318 ± 174	1294 ± 223
ke (h−1)	1.1 ± 0.0	2.2 ± 0.6	1.4 ± 0.3	1.6 ± 0.3	2.8 ± 0.8
Fabs (%)	100 ± 3	67 ± 13	58 ± 4	64 ± 8	67 ± 9

C_max, AUC_0–∞, CL, k_e and F_abs are expressed as mean ± SEM, t_max is expressed as the median [Q1; Q3] (25% and 75% percentile) from six rats.

^*Significant difference from oral administration of 120 mg kg⁻¹ acetaminophen (P < 0.05).