Table 5.
ka values calculated from vigabatrin deconvolution curves (DC) and plasma concentration time profiles (PC), using the estimated kempty values and fitting to eqs. (9) or (10), respectively.
| Vigabatrin (mg kg−1) | 1 | 10 | ||
|---|---|---|---|---|
| Profile fitted | PC | DC | PC | DC |
| Control | 3.3 ± 0.4 | 7.9 ± 1.9 | 3.4 ± 0.4 | 8.1 ± 2.3 |
| Milk | 2.8 ± 0.3 | 5.3 ± 0.9 | 2.6 ± 0.3 | 4.1 ± 0.5 |
| Low fat milk | 2.6 ± 0.1 | 5.2 ± 0.3 | 2.6 ± 0.1 | 5.0 ± 0.3 |
| Sar | 1.6 ± 0.1* | 2.9 ± 0.2* | 1.7 ± 0.1* | 3.2 ± 0.2* |
| Pro/Trpa | 1.9 ± 0.2* | 4.0 ± 0.6 | ||
| BCHa | 2.4 ± 0.2 | 5.8 ± 1.7 | ||
*
Significant difference from control (P < 0.05).
ka values were estimated on the basis of kempty values for the control situation.