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. 2014 Oct 3;9(10):e107939. doi: 10.1371/journal.pone.0107939

Figure 5. Domain structure and organization of Cluster 2 genes in B. microti and other apicomplexan parasites.

Figure 5

A. Comparison of ClpC domain structure between B. microti, P. falciparum, T. gondii and Chromera sp. B. microti apicoplast genome encodes two ClpC proteins that lack the N-terminus part as revealed by Pfam and TMpred predictions. Other apicomplexan ClpC structures have been obtained from Pfam database using UNIPROT accession numbers. Two PfamA domains are found in ClpC proteins of apicomplexa: AAA_2 (ATPase catalytic function) and ClpB_D2-small (conserved C-terminal domain). Light grey boxes indicate regions of low complexity. Transmembrane domains were predicted by Pfam only for T. gondii ClpC proteins (TM). B. Gene organization of cluster 2. The tRNA genes of cluster 2, which are conserved in all three apicoplast genomes are in bold. Three putative genes, C, D and E present at 3′ end of B. microti cluster 2 have no significant homologies with each other and lack homologs in other parasites.