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. 2014 Oct 3;9(10):e108657. doi: 10.1371/journal.pone.0108657

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© 2014 de Mendonca et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Clustergram showing the expression profile of significantly (p<0.05) altered genes related to the cell cycle in the adrenal ZF fraction after inhibition of the HPA axis with DEX for two days (50 µg/100 g BW), followed by ACTH, N-POMC^Met, or N-POMC^Cys treatments (A). Correlation of up- or down-regulated genes in the ZF fraction after treatments, showing the number of genes regulated by both treatments with POMC-derived peptides (B). Up- or down-regulated genes related to specific cell cycle phases after ACTH, N-POMC^Met, or N-POMC^Cys treatments (C). G1: G1 phase and G1/S transition; G2: G2 phase; S: S phase and DNA replication; M: M phase.