. 2014 Oct 3;9(10):e108657. doi: 10.1371/journal.pone.0108657

Table 2. Genes significantly regulated in the ZG fraction of the adrenal cortex after inhibition of the HPA axis followed by treatments with ACTH, N-POMC^Met, or N-POMC^Cys.

ZG Fraction: ACTH
Gene Symbol	Gene	Fold Regulation	p-value
Camk2a	Calcium/calmodulin-dependent protein kinase II alpha	3.0417	0.000054
Cdk4	Cyclin-dependent kinase 4	1.9117	0.011247
Dst	Dystonin	1.8402	0.013247
Ppm1d	Protein phosphatase 1D magnesium-dependent. delta isoform	1.8084	0.006493
Pmp22	Peripheral myelin protein 22	1.58	0.004287
Rad9	RAD9 homolog (S. pombe)	1.5261	0.026327
Chek1	CHK1 checkpoint homolog (S. pombe)	1.3946	0.038051
Ccne1	Cyclin E1	1.3866	0.044238
Abl1	C-abl oncogene 1. receptor tyrosine kinase	1.3409	0.010445
Dnajc2	DnaJ (Hsp40) homolog. subfamily C. member 2	1.2555	0.035768
Notch2	Notch homolog 2 (Drosophila)	1.1974	0.010077
Gpr132	G protein-coupled receptor 132	1.0942	0.024599
Ccnc	Cyclin C	−1.4141	0.042834
Cdkn1a	Cyclin-dependent kinase inhibitor 1A	−1.4708	0.024637
Ccnd1	Cyclin D1	−1.5074	0.02811
Prm1	Protamine 1	−1.5085	0.038924
Msh2	MutS homolog 2 (E. coli)	−1.6135	0.027143
Pkd1	Polycystic kidney disease 1 homolog (human)	−1.8617	0.000053
Ccna1	Cyclin A1	−2.5344	0.012597

ZG Fraction: N-POMC^Met
Gene Symbol	Gene	Fold Regulation	p-value
Mre11a	MRE11 meiotic recombination 11 homolog A (S. cerevisiae)	1.8348	0.021743
Psmg2	Proteasome (prosome. macropain) assembly chaperone 2	1.824	0.007304
Pcna	Proliferating cell nuclear antigen	1.6431	0.000977
Pes1	Pescadillo homolog 1. containing BRCT domain (zebrafish)	1.598	0.047391
Inha	Inhibin alpha	1.5662	0.016083
Dnajc2	DnaJ (Hsp40) homolog. subfamily C. member 2	1.4394	0.037783
Cdk5rap1	CDK5 regulatory subunit associated protein 1	1.4382	0.003531
LOC367976	Similar to DNA replication licensing factor MCM3(DNA polymerase alphaholoenzyme-associated protein P1) (P1-MCM3)	1.3475	0.021984
Ran	RAN. member RAS oncogene family	1.2062	0.020662
Ccnb2	Cyclin B2	−1.2335	0.012467
Ccnc	Cyclin C	−1.2537	0.014855
Ccnf	Cyclin F	−1.2646	0.031889
Ccne1	Cyclin E1	−1.4087	0.034054
Bcl2	B-cell CLL/lymphoma 2	−1.4235	0.034361
Rad21	RAD21 homolog (S. pombe)	−1.4703	0.001876
Rbl2	Retinoblastoma-like 2	−1.4703	0.017071
Gpr132	G protein-coupled receptor 132	−1.4714	0.000172
Stag1	Stromal antigen 1	−1.4994	0.018796
Ppp3ca	Protein phosphatase 3. catalytic subunit. alpha isoform	−1.5327	0.007328
Cdkn1b	Cyclin-dependent kinase inhibitor 1B	−1.5434	0.020993
Ppp2r3a	Protein phosphatase 2. regulatory subunit B”. alpha	−1.5667	0.010109
Itgb1	Integrin. beta 1	−1.7364	0.009488
Ak1	Adenylate kinase 1	−1.8606	0.000275
E2f3	E2F transcription factor 3	−1.8675	0.011247
RGD1566319	Similar to Sestrin 2 (Hi95)	−1.8804	0.000178
Apbb1	Amyloid beta (A4) precursor protein-binding. family B. member 1 (Fe65)	−1.8871	0.015075
Pkd1	Polycystic kidney disease 1 homolog (human)	−1.9341	0.00016
Cdkn1a	Cyclin-dependent kinase inhibitor 1A	−2.0881	0.007196
Cdkn2a	Cyclin-dependent kinase inhibitor 2A	−2.202	0.010674

ZG Fraction: N-POMC^Cys
Gene Symbol	Gene	Fold Regulation	p-value
Camk2a	Calcium/calmodulin-dependent protein kinase II alpha	1.7687	0.001738
Gadd45a	Growth arrest and DNA-damage-inducible. alpha	1.594	0.031285
Inha	Inhibin alpha	1.455	0.014103
Ppp3ca	Protein phosphatase 3. catalytic subunit. alpha isoform	−1.311	0.028009
Ppp2r3a	Protein phosphatase 2. regulatory subunit B”. alpha	−1.4132	0.022207
Terf1	Telomeric repeat binding factor (NIMA-interacting) 1	−1.433	0.023569
Ccnc	Cyclin C	−1.4546	0.016437
Tfdp2	Transcription factor Dp-2 (E2F dimerization partner 2)	−1.4614	0.017254
E2f3	E2F transcription factor 3	−1.5025	0.016275
Shc1	SHC (Src homology 2 domain containing) transforming protein 1	−1.5025	0.01852
Itgb1	Integrin. beta 1	−1.5447	0.023496
Rbl2	Retinoblastoma-like 2	−1.5735	0.032006
Notch2	Notch homolog 2 (Drosophila)	−1.5881	0.002803
Ccna2	Cyclin A2	−1.6122	0.012739
Stag1	Stromal antigen 1	−1.6178	0.028532
Rad21	RAD21 homolog (S. pombe)	−1.6594	0.014072
Mcm2	Minichromosome maintenance complex component 2	−1.6613	0.013286
Cdkn1a	Cyclin-dependent kinase inhibitor 1A	−1.7021	0.028311
Rad9	RAD9 homolog (S. pombe)	−1.7319	0.04898
Skp2	S-phase kinase-associated protein 2 (p45)	−1.7621	0.029069
Ak1	Adenylate kinase 1	−1.8412	0.000319
RGD1566319	Similar to Sestrin 2 (Hi95)	−1.9417	0.000214
Apbb1	Amyloid beta (A4) precursor protein-binding. family B. member 1 (Fe65)	−1.9757	0.01365
Gpr132	G protein-coupled receptor 132	−1.9779	0.000082
Tp53	Tumor protein p53	−2.1997	0.003929
Prm1	Protamine 1	−2.2694	0.007761
Ccnf	Cyclin F	−3.3807	0.000503
Nek2	NIMA (never in mitosis gene a)-related expressed kinase 2	−3.8655	0.002508
Pkd1	Polycystic kidney disease 1 homolog (human)	−4.1911	0.000004
Tp63	Tumor protein p63	−4.8422	0.000526

Table 2. Genes significantly regulated in the ZG fraction of the adrenal cortex after inhibition of the HPA axis followed by treatments with ACTH, N-POMCMet, or N-POMCCys.

Table 2. Genes significantly regulated in the ZG fraction of the adrenal cortex after inhibition of the HPA axis followed by treatments with ACTH, N-POMC^Met, or N-POMC^Cys.