Table 5. Associations of the components of WCRF/AICR index score and prostate cancer risk by cancer stage.a.
| Score | Control n | Overall prostate cancer | Localised | Locally advanced | Locally advanced vs. Localised | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
|||||||||||||
| n | OR (95% CI) | P tren d | n | OR (95% CI) | P trend | n | OR (95% CI) | P trend | OR (95% CI) | P trend | |||
| Body Fatness | 0 to 0.25 | 5,007 | 747 | 1 | 679 | 1 | 65 | 1 | 1 | ||||
| 0.5 | 2,928 | 448 | 1.02 (0.90, 1.16) | 390 | 0.97 (0.84, 1.10) | 52 | 1.37 (0.95, 1.99) | 1.38 (0.93, 2.05) | |||||
| 0.75 | 1,998 | 293 | 0.96 (0.83, 1.11) | 264 | 0.95 (0.81, 1.10) | 29 | 1.16 (0.74, 1.81) | 1.18 (0.73, 1.90) | |||||
| 1 | 2,072 | 318 | 1.00 (0.87, 1.16) | 279 | 0.96 (0.82, 1.11) | 38 | 1.48 (0.98, 2.24) | 1.58 (1.01, 2.45) | |||||
| Dose-responseb | 1.01 (0.97, 1.05) | 0.73 | 1.00 (0.96, 1.04) | 0.85 | 1.11 (0.99, 1.24) | 0.08 | 1.11 (0.99, 1.26) | 0.08 | |||||
| Physical activity | 0 | 4,796 | 688 | 1 | 602 | 1 | 80 | 1 | 1 | ||||
| 0.5 | 3,956 | 610 | 1.08 (0.96, 1.21) | 559 | 1.13 (1.00, 1.28) | 47 | 0.71 (0.49, 1.03) | 0.62 (0.42, 0.93) | |||||
| 1 | 3,253 | 508 | 1.10 (0.97, 1.24) | 451 | 1.11 (0.97, 1.27) | 57 | 1.03 (0.72, 1.46) | 0.96 (0.65, 1.41) | |||||
| Dose-responsec | 1.05 (0.98, 1.12) | 0.14 | 1.06 (0.99, 1.13) | 0.09 | 1.00 (0.83, 1.20) | 0.96 | 0.96 (0.79, 1.18) | 0.71 | |||||
| Foods and drinks that promote weight gain | 0 to 0.25 | 2,948 | 438 | 1 | 386 | 1 | 51 | 1 | 1 | ||||
| 0.5 | 4,005 | 607 | 1.01 (0.88, 1.15) | 545 | 1.03 (0.90, 1.19) | 60 | 0.85 (0.58, 1.24) | 0.79 (0.52, 1.20) | |||||
| 0.75 | 3,890 | 606 | 1.04 (0.91, 1.20) | 545 | 1.07 (0.92, 1.23) | 54 | 0.79 (0.53, 1.17) | 0.75 (0.49, 1.15) | |||||
| 1 | 1,162 | 155 | 0.91 (0.74, 1.12) | 136 | 0.91 (0.73, 1.12) | 19 | 1.02 (0.58, 1.78) | 1.06 (0.58, 1.95) | |||||
| Dose-responseb | 1.00 (0.95, 1.06) | 0.96 | 1.00 (0.95, 1.06) | 0.97 | 0.99 (0.85, 1.15) | 0.86 | 0.98 (0.83, 1.16) | 0.81 | |||||
| Plant foods | 0 to 0.25 | 1,063 | 165 | 1 | 145 | 1 | 18 | 1 | 1 | ||||
| 0.5 | 2,456 | 398 | 1.04 (0.85, 1.27) | 355 | 1.04 (0.84, 1.28) | 41 | 1.06 (0.60, 1.87) | 0.99 (0.54, 1.83) | |||||
| 0.75 | 2,547 | 403 | 1.00 (0.82, 1.22) | 357 | 0.99 (0.80, 1.22) | 44 | 1.10 (0.62, 1.95) | 1.02 (0.55, 1.90) | |||||
| 1 | 5,939 | 840 | 0.87 (0.72, 1.06) | 755 | 0.87 (0.71, 1.06) | 81 | 0.88 (0.51, 1.54) | 0.95 (0.52, 1.74) | |||||
| Dose-responseb | 0.94 (0.89, 0.99) | 0.02 | 0.94 (0.89, 0.99) | 0.02 | 0.94 (0.81, 1.09) | 0.45 | 0.98 (0.83, 1.15) | 0.81 | |||||
| Animal foods | 0 | 8,277 | 1,230 | 1 | 1,094 | 1 | 130 | 1 | 1 | ||||
| 0.5 | 3,129 | 511 | 1.09 (0.97, 1.22) | 458 | 1.10 (0.98, 1.24) | 50 | 1.01 (0.72, 1.42) | 0.94 (0.65, 1.35) | |||||
| 1 | 599 | 65 | 0.73 (0.56, 0.96) | 60 | 0.76 (0.58, 1.01) | 4 | 0.43 (0.16, 1.19) | 0.61 (0.22, 1.74) | |||||
| Dose-responsec | 0.98 (0.89, 1.07) | 0.61 | 0.99 (0.90, 1.09) | 0.84 | 0.86 (0.65, 1.14) | 0.28 | 0.88 (0.65, 1.20) | 0.43 | |||||
| Alcohol | 0 | 3,745 | 559 | 1 | 500 | 1 | 55 | 1 | 1 | ||||
| 0.5 | 1,788 | 259 | 0.97 (0.83, 1.14) | 232 | 0.96 (0.82, 1.14) | 26 | 1.02 (0.64, 1.65) | 1.16 (0.70, 1.94) | |||||
| 1 | 6,472 | 8 | 1.00 (0.90, 1.13) | 880 | 1.00 (0.88, 1.12) | 103 | 1.10 (0.78, 1.55) | 1.12 (0.77, 1.62) | |||||
| Dose-responsec | 1.00 (0.95, 1.06) | 0.89 | 1.00 (0.94, 1.06) | 0.98 | 1.05 (0.89, 1.25) | 0.58 | 1.05 (0.88, 1.26) | 0.58 | |||||
a
Adjusted for age (continuous variable), recruitment centre, family history of prostate cancer, smoking status and total energy intake (kcal/d). All components were mutually adjusted for each other except for the ‘foods and drinks that promote weight gain‘ component.
b
Odds ratios and 95% CI per 0.25 score increment.
c
Odds ratios and 95% CI per 0.5 score increment
d
P-values for trend were calculated by modeling components of WCRF/AICR score as a continuous variable.