Table 3.
Relevant Toxicities Observed Among Enrolled Subjects
| Toxicitya N (%) | Grade | ||
|---|---|---|---|
| 2 | 3 | 4 | |
| Anemia | 21 (32%) | 3 (5%) | 1 (1.5%) |
| Neutropenia | 16 (24%) | 11 (17%) | 6 (9%) |
| Thrombocytopenia | 1 (1.5%) | - | - |
| Hypoalbuminemia | 18 (27%) | 3 (5%) | - |
| Hypomagnesemia | 10 (15%) | 4 (6%) | - |
| Renal (creatinine) | - | 1 (1.5%) | - |
| Hypersensitivity Reaction | 1 (1.5%) | - | - |
| Tinnitus | 5 (7.5%) | - | - |
| Fatigue | 29 (44%) | 13 (20%) | 2 (3%) |
| Xeroderma | 14 (21%) | 1 (1.5%) | - |
| Acneiform rash | 27 (41%) | 17 (26%) | - |
| Dehydration | 9 (14%) | 13 (20%) | - |
| Anorexia | 15 (23%) | 22 (33%) | 1 (1.5%) |
| Dysphagia | 16 (24%) | 29 (44%) | 1 (1.5%) |
| Xerostomia | 14 (21%) | 11 (17%) | - |
| Mucositis | 19 (29%) | 34 (52%) | 2 (3%) |
| Nausea + Vomiting | 20 (30%) | 14 (21%) | - |
| Neurosensory | 2 (3%) | - | - |
a
One grade 5 treatment-related event occurred as a result of infection.