Table 2.
Associations of GBV-C infection with NHL overall and NHL subtypes
| GBV-C RNA Positivitya | E2 Antibody Positivityb | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Total N | N | % | OR | 95% | CI | N | % | OR | 95% | CI | |
| Controls | 1,316 | 7 | 0.53 | 1.00 | (reference) | 84 | 6.38 | 1.00 | (reference) | ||
| All NHL cases | 658 | 12 | 1.82 | 3.43 | (1.35 | , 8.71) | 45 | 6.84 | 1.08 | (0.74 | , 1.58) |
| NHL cases, by subtype | |||||||||||
| Diffuse large B-cell lymphoma | 145 | 4 | 2.76 | 5.31 | (1.54 | , 18.36) | 8 | 5.52 | 0.86 | (0.41 | , 1.81) |
| Follicular lymphoma | 88 | 2 | 2.27 | 4.35 | (0.89 | , 21.26) | 1 | 1.14 | 0.17 | (0.02 | , 1.23) |
| CLL/SLL | 249 | 4 | 1.61 | 3.05 | (0.89 | , 10.51) | 19 | 7.63 | 1.21 | (0.72 | , 2.03) |
| Other NHL | 119 | 1 | 0.84 | 1.59 | (0.19 | , 13.00) | 14 | 11.76 | 1.96 | (1.07 | , 3.56) |
| Unknown NHL subtype | 52 | 1 | 1.92 | 3.67 | (0.44 | , 30.37) | 3 | 5.77 | 0.90 | (0.27 | , 2.94) |
Abbreviations: OR, odds ratio; CI, confidence interval; NHL, non-Hodgkin lymphoma; CLL/SLL, chronic lymphocytic leukemia/small lymphocytic lymphoma
a
Referent group is RNA-negative subjects.
b
Referent group is E2 antibody-negative subjects.