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. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: Cancer Discov. 2014 Aug 6;4(10):1198–1213. doi: 10.1158/2159-8290.CD-14-0157

Figure 2. Base excision repair genes are up-regulated in pGBM and adult gliomas.

Figure 2

a. Immunohistochemistry analysis of 72 pediatric GBM samples demonstrating strong nuclear, cytoplasmic or negative staining. Scale bar =20um.

b. Kaplan Meir survival curve analysis of patients staining positive for MPG or negative. Log rank p=0.016.

c–h. RNA gene-expression analysis of base excision repair proteins downstream of MPG in pediatric GBM (pGBM, n=53) compared to normal human brain (NB, n=172). ***P<0.001.

i. Copy number alterations identify 20/40 BER DNA repair genes are significantly altered in 47 pediatric high grade gliomas. Gains were established as 2.5 more copies of tumor DNA per gene compared to matched normal controls and losses were established as 1.5 copies or less of tumor DNA compared to normal control tissue both corrected at a false discovery rate (q-value) of <5%.