Table.1.

Table showing the different chemical compounds, drugs and their targets in mitochndria. These drugs and chemical compounds targeting the oxidative stress pathways, neuroinflammatory pathways, some of targeting electron transport chain. These drugs and compounds are widely used for the study of neurodegenerative disease.

S. No.	Compounds	Mechanism	Structure	Trade name	References
1	CDDO-Ethyl amide	Target Nrf2/ARE (NF-E2-related factor 2/antioxidant response element) signaling pathway		Not assigned	[102, 103]
2	CDDO-Trifluroethylamide	Target Nrf2/ARE (NF-E2-related factor 2/antioxidant response element) signaling pathway, attenuates mitochondria l dysfunction		Not assigned	[102, 103]
3	Pioglitazone	Activate peroxisome proliferator-activated receptors (PPARs), provide neuroprotection, attenuates mitochondria l dysfunction by improving mitochondria l DNA (mtDNA) content, levels of mtDNA and nuclearencoded electron transport chain subunit proteins, increased oxygen consumption, and elevated complex I and complex IV V max activities		Actos Piomed Pioneer	[104, 105]
4	Rosiglitazone	Activate PPAR gamma activators, attenuates mitochondria l dysfunction.		NA	[106]
5.	Resveratrol	Antioxidant, anti-inflammatory, and metalchelating effects, prevent mitochondria l dysfunction		Not assigned	[107].
6.	5-aminoimidazo le-4-carboxamide ribonucleoside (AICAR)	Block proinflammatory cytokines, inhibit ROS generation, deplete glutathione, prevent oxidative stress		Huapin	[108].
7	Coenzyme Q10	Improve respiratory chain dysfunction, oxidative stress and neurodegeneration		Rite Aid Coenzyme Q-10	[109, 110]
8.	Bezafibrate	Anti-inflammatory, neuroprotective role, attenuate astrogliosis, improve peroxisome proliferator-activated receptor (PPAR)-γ-		Bezalip Beza–XL Fenolip Globez	[111, 112]