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. Author manuscript; available in PMC: 2015 Oct 1.
Published in final edited form as: Cancer Res. 2014 Jul 31;74(19):5386–5396. doi: 10.1158/0008-5472.CAN-14-1210

Figure 5.

Figure 5

The insets show the distribution of remaining APL stem cells for (a) 90 days of continued ATRA treatment and (b) 340 days of continued ATRA treatment due to stochastic individual based simulations with the parameters from Table 1 and 2. After 340 days of ATRA treatment almost 60% of patients are expected to be cancer stem cell free and thus potentially cured. The main panels shows the expected relapse time of patients where elimination of cancer stem cells was not achieved, depending on the size of the remaining pool of cancer stem cells. These relapse times correspond well with observations in clinical studies.