Table 2.
Overall (%) | pSTAT3+ (%) | pSTAT3− (%) | P value | |
---|---|---|---|---|
MYC expression | 260/398 (65) | 61/65 (94) | 199/333 (60) | <0.001 |
BCL2 expression | 192/398 (48) | 35/66 (53) | 157/332(47) | 0.420 |
MYC/BCL2 co-expression | 130/396 (33) | 34/65 (52) | 96/331 (29) | 0.001 |
BCL2 rearranged | 69/378 (18) | 7/59 (12) | 62/319 (19) | 0.201 |
BCL6 rearranged | 107/321 (33) | 20/50 (40) | 87/271 (32) | 0.327 |
MYC rearranged | 35/382 (9) | 4/62 (6) | 31/320 (10) | 0.630 |
Double hit* | 13/287 (5) | 1/42 (2) | 12/245 (5) | 0.700 |
TP53 deletion | 47/402 (12) | 5/67 (7) | 42/335 (13) | 0.300 |
TP53 mutated | 91/408 (22) | 13/67 (19) | 78/341 (23) | 0.631 |
p53 expression | 140/395 (36) | 27/66 (41) | 113/329 (34) | 0.326 |
p50 expression | 154/428 (36) | 27/70 (39) | 127/358 (35) | 0.683 |
p52 expression | 119/422 (28) | 27/71 (38) | 92/351 (26) | 0.050 |
p65 expression | 144/428 (34) | 27/71 (38) | 117/357 (33) | 0.411 |
cRel expression | 99/422 (24) | 13/67 (19) | 86/355 (24) | 0.436 |
p50/p65 co-expression | 77/422 (18) | 14/70 (20) | 63/352 (18) | 0.735 |
p50/cRel co-expression | 47/420 (11) | 6/67 (9) | 41/353 (12) | 0.674 |
p52/p65 co-expression | 41/414 (10) | 11/70 (16) | 30/344 (9) | 0.081 |
p52/cRel co-expression | 44/406 (11) | 6/66 (9) | 38/340 (11) | 0.829 |
Classical NF-κB expression | 100/427 (23) | 15/70 (21) | 85/357 (24) | 0.758 |
Alternative NF-κB expression | 71/417 (17) | 12/70 (17) | 59/347 (17) | 1.000 |
NF-kB expression** | 134/417 (32) | 20/69 (29) | 114/348 (33) | 0.575 |
CD30 expression | 72/439 (16) | 12/72 (17) | 60/367 (16) | 1.000 |
pAKT expression | 76/435 (17) | 17/71 (24) | 59/364 (16) | 0.125 |
Cyclin D1 expression | 10/432 (2) | 2/71 (3) | 8/361 (2) | 0.672 |
pSTAT3, phosphorylated STAT3
double hit, MYC and BCL2 or BCL6 rearrangements
Summation of the classical and alternative NF-κB pathway expression