Table 2.

Effect of BMI and waist size on risk of obesity-related cancers in men and women

BMI (kg/m2)	Lean (<25)	Overweight (25-<30)	Obese (≥ 30)
All Subjects
No.	1,528	1,647	588
Cancer cases/Person-Yearsa	130/26,699	185/28,463	70/9,140
IR/10,000 Person-Years	48.7	65.0	76.6
HR (95% CI)
Unadjusted	1.0 (Reference)	1.3 (1.1-1.7)	1.7 (1.2-2.2)
Adjustedb	1.0 (Reference)	1.5 (1.2-1.9)	1.7 (1.3-2.3)
Males
Cancer cases/Person-Yearsa	22/8,748	67/13,961	16/3,060
IR/10,000 Person-Years	25.1	48.0	52.3
HR (95% CI)
Unadjusted	1.0 (Reference)	1.9 (1.2-3.1)	2.3 (1.2-4.4)
Adjustedb	1.0 (Reference)	1.9 (1.2-3.1)	2.3 (1.2-4.4)
Females
Cancer cases/Person-Yearsa	108/17,951	118/14,502	54/6,081
IR/10,000 Person-Years	60.2	81.4	88.8
HR (95% CI)
Unadjusted	1.0 (Reference)	1.4 (1.0-1.8)	1.5 (1.1-2.1)
Adjustedb	1.0 (Reference)	1.4 (1.1-1.8)	1.6 (1.2-2.3)

WAIST (cm)	<84 (m), <81 (f)	84-<94 (m), 81-<91 (f)	≥94 (m), ≥91 (f)
All Subjects
No.	517	1,567	1,679
Cancer cases/Person-Yearsa	31/8,166	135/27,520	219/28,616
IR/10,000 Person-Years	38.0	49.1	76.5
HR (95% CI)
Unadjusted	1.0 (Reference)	1.2 (0.84-1.8)	1.9 (1.3-2.8)
Adjustedb	1.0 (Reference)	1.2 (0.79-1.7)	1.8 (1.2-2.6)
Males	<84	84-<94	≥94
Cancer cases /Person-Yearsa	6/4,352	41/11,786	58/9,630
IR/10,000 Person-Years	13.8	34.8	60.2
HR (95% CI)
Unadjusted	1.0 (Reference)	2.4 (1.0-5.7)	4.4 (1.9-10.1)
Adjustedb	1.0 (Reference)	2.2 (0.93-5.2)	3.9 (1.7-9.1)
Females	<81	81-<91	≥91
Cancer cases/Person-Yearsa	25/3,815	94/15,733	161/18,986
IR/10,000 Person-Years	65.5	59.7	84.8
HR (95% CI)
Unadjusted	1.0 (Reference)	0.88 (0.57-1.4)	1.3 (0.82-1.9)
Adjustedb	1.0 (Reference)	0.89 (0.57-1.4)	1.3 (0.86-2.0)

BMI=body mass index; CI=confidence interval; HR=hazard ratio; IR=incidence rate

^aFollow-up time begins 4 years after end of exposure period.

^bAdjusted for age, sex (in all-subjects models), height, education, alcohol, cigarettes/day, and physical activity