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. Author manuscript; available in PMC: 2015 Oct 2.
Published in final edited form as: Mol Cell. 2014 Sep 15;56(1):140–152. doi: 10.1016/j.molcel.2014.08.014

Figure 6. A Model for the Opposing Function of Snai1 and Snai2 In Reprogramming.

Figure 6

(A) Transcriptional activation of Snai1, but not Snai2, by Nanog during pre-iPSC reprogramming.

(B) Summary of regulatory loops controlled by the Nanog-Snai1 complex and mutual inhibition of Snai1 and Snai2 in transcriptional control of pluripotency-associated genes and miRNAs. Red colored signs denote the novel regulatory controls defined in this study. Grey lines denote the regulatory controls indicated but not yet defined in this study. Black lines are the regulatory controls already established from the published literature.

(C) Summary of the salient features of functional antagonisms of Snai1 versus Snai2 (indicated by mutual inhibition) and Let7 versus miR-290-295, as well as the physical and functional cooperation of Nanog and Snai1 during the pre-iPSC to iPSC transition. The red two-pointed arrow denotes the protein-protein interaction between Nanog and Snai1. See also Figure S6.