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. Author manuscript; available in PMC: 2015 Oct 1.
Published in final edited form as: Clin Cancer Res. 2014 Aug 12;20(19):5085–5096. doi: 10.1158/1078-0432.CCR-14-1038

Figure 3. Abrogation of olaparib and radiation-induced G2 checkpoint by AZD1775.

Figure 3

MiaPaCa-2 cells were treated with AZD1775/olaparib (200nM/1uM, respectively) for 1 hour pre- and 6 (top) or 16 (bottom) hours post-RT (6Gy) and then analyzed for pHistone H3 and DNA content by flow cytometry. The percentages of cells in each phase of the cell cycle are indicated. Data are from single representative experiments. A summary of n=2 independent experiments is included in Suppl. Fig. 1.