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. Author manuscript; available in PMC: 2015 Oct 1.
Published in final edited form as: Clin Cancer Res. 2014 Aug 12;20(19):5085–5096. doi: 10.1158/1078-0432.CCR-14-1038

Figure 6. Radiosensitization of pancreatic tumor xenografts by combined treatment with AZD1775 and olaparib.

Figure 6

Athymic nude mice bearing bilateral, flank MiaPaCa-2 xenografts were treated with AZD1775 (60mg/kg; BID; 1h pre- and 4h post-RT; Mon–Fri), olaparib (60mg/kg, QD, 1h pre-RT; Mon–Fri), and radiation (RT; 1.8Gy/fraction; Mon–Fri) for one cycle as illustrated (A). B, Tumor volumes were normalized to the first day of treatment (day 0) and are the mean ± SE of 10–16 tumors per treatment group. Data shown are for the latest time point (17–42 days) before censoring occurred due to animals being removed from study due to tumor burden. C, The median time required for tumor volume doubling is illustrated with lower and upper limits in parentheses. Statistical significance (P<0.05) is indicated vs control*, RT†, AZD1775+RT‡, and olaparib+RT¥. C, The Kaplan-Meier plot illustrates the proportion of tumors doubled in volume within the full 90 day monitoring period.