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Design considerations under the VS approach: relative efficiency as a function of k, for fixed n versus fixed N = nk, with π = 0.05, 0.005 and Sp = 0.995, with and without a dilution effect (see Section 3.2 for details). In the case of fixed n, we set υ = m/n = 0.1. In the case of fixed N, we set m/N = 0.001 for π = 0.05 and 0.0002 for π = 0.005.
