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. Author manuscript; available in PMC: 2015 Nov 10.
Published in final edited form as: Stat Med. 2014 Jul 18;33(25):4482–4500. doi: 10.1002/sim.6268

Table 1.

The mis-substitution bias: relative bias for π and absolute bias for λ = logit(π) due to misspecifying one or both of (Se = 0.95, Sp = 0.995), evaluated for the limiting case that n → ∞ (see Section 2 for details). “NA” indicates that the limit of π̂sbt is undefined or out of range.

Prevalence (π) Group Size (k) Specified Values of (Se, Sp)
(0.95, 1) (0.95, 0.99) (1, 0.995) (0.9, 0.995) (1, 1) (0.9, 0.99)
relative bias for π
0.05 1 0.10 −0.10 −0.05 0.06 0.05 −0.05
5 0.02 −0.02 −0.06 0.06 −0.04 0.04
15 0.01 −0.01 −0.07 0.08 −0.07 0.08
50 0.00 0.00 −0.18 0.42 −0.18 0.41
150 0.00 0.00 −0.61 NA −0.61 NA
0.005 1 1.05 NA −0.05 0.06 0.95 NA
5 0.21 −0.21 −0.05 0.06 0.15 −0.17
15 0.07 −0.07 −0.05 0.06 0.01 −0.02
50 0.02 −0.02 −0.06 0.06 −0.04 0.04
150 0.01 −0.01 −0.07 0.09 −0.07 0.08

bias for λ = logit(π)
0.05 1 0.10 −0.11 −0.05 0.06 0.05 −0.05
5 0.02 −0.02 −0.06 0.06 −0.04 0.04
15 0.01 −0.01 −0.08 0.09 −0.07 0.08
50 0.00 0.00 −0.21 0.37 −0.21 0.37
150 0.00 0.00 −0.96 NA −0.96 NA
0.005 1 0.72 NA −0.05 0.05 0.67 NA
5 0.19 −0.24 −0.05 0.06 0.14 −0.18
15 0.07 −0.07 −0.05 0.06 0.01 −0.02
50 0.02 −0.02 −0.06 0.06 −0.04 0.04
150 0.01 −0.01 −0.08 0.08 −0.07 0.08